We are focusing on the role of biomechanical force generated by fluid flow from blood vessels, lymph node, interstitial flow and cerebrospinal fluid.
Our ongoing researches are as below.
1. Immune escape mechanisms of cancer cells can be regulated by altered biomechanical stimuli of tumor microenvironment.
2. Brain microenvironment is changed with aging process. Altered micoenvironment can initiate neuronal and glial cell malfunction which are corresponding to trigger neurodegeneration.
3. By modulating biological microenvironment, it is possible to enhance the immunomodulatory and anti-inflammatory function of human mesenchymal stromal cells and overcome the limitation of cell therapy.
The altered brain microenvionment by aging
The alterations in the brain microenvironment resulting from aging elicit distinct molecular mechanisms in both neuronal and glial cells, brought about by modifications in diverse physical conditions
Maximizing anti-inflammatory response and immunomodulatory function of MSCs with biomimetic stimuli
Bone marrow derived mesenchymal stromal cells are exposed to biomimetic mechanical stimuli (wall shear stress) using microfludics system.
Anti-inflammation and immune modulation related function of MSCs are highly enhanced by fluid shear stress which maximize immunomodulatory function of MSCs for the application of translational medicine.
Lymphatic fluid flow mimicking system enhances metastatic features of cancers
Biophysical cues in tumor microenvironment are shear stress, compression forces, hydrostatic pressures, etc.
Lymphatic drainage mimicking system demonstrates tumor progression within tumor microenvironment. Interstitial fluid flow or lymphatic fluid flow significantly enhanced tumor metastatic features such as cancer cell migration and MMP activity through YAP/TAZ.
More interesting researches are on-going now.
For more detail, please contact us.